32-bit PHP and the 2 GB file limit

The 32-bit version of PHP(5) is limited to files with a maximum size of 2 GB.

Which functions seems to be affected, and therefore may need a workaround for files bigger than 2 GB?

filesize() - Fails on files, custom versions based on execution of the ls command through exec are available
is_file() - Fails, use is_link() and is_dir() ?
fopen() - Fails opening files, use sed, awk etc.?